Multi-Disciplinary Approach to the Study of Chronic Pelvic Pain

2023

Farrar JT, Locke KT Jr., Clemens JQ, Griffith JW, Harte SE, Kirkali Z, Kreder KJ, Krieger JN, Lai HH, Moldwin RM, Mullins C, Naliboff BD, Pontari MA, Rodriguez LV, Schaeffer AJ, Schrepf A, Stephens-Shields A, Sutcliffe S, Taple BJ, Williams DA, Landis JR.
Widespread Pain Phenotypes Impact Treatment Efficacy Results in Randomized Clinical Trials for Interstitial Cystitis/ Bladder Pain Syndrome: A MAPP Network Study. Res Sq. 2023 Feb 23;rs.3.rs-2441086. doi: 10.21203/rs.3.rs-2441086/v1. Preprint. PMID: 36865104.
PMC9980200
Journal.
Keywords: Randomized controlled trials; Pain/Chronic pain; Epidemiology; Functional clustering.

Lutgendorf SK, Zia S, Luo Y, O'Donnell M, van Bokhoven A, Bradley CS, Gallup R, Pierce J, Taple BJ, Naliboff BD, Quentin Clemens J, Kreder KJ, Schrepf A.
Early and recent exposure to adversity, TLR-4 stimulated inflammation, and diurnal cortisol in women with interstitial cystitis/bladder pain syndrome: A MAPP research network study. Brain Behav Immun. 2023 Jul;111:116-123. doi: 10.1016/j.bbi.2023.03.024. Epub 2023 Mar 29. PMID: 37001828.
PMCID: online ahead of print
Journal.
Keywords: Chronic stress; Cortisol; Early life adversity; HPA axis; IC/BPS; Inflammation; Interstitial cystitis; Pain; Recent life adversity.

Pierce J, Harte SE, Afari N, Bradley CS, Griffith JW, Kim J, Lutgendorf S, Naliboff BD, Rodriguez LV, Taple BJ, Williams D, Harris RE, Schrepf A.
Mediators of the association between childhood trauma and pain sensitivity in adulthood: a MAPP Research Network analysis.Pain. 2023 May 5. doi: 10.1097/j.pain.0000000000002895. Online ahead of print. PMID: 37144687
PMCID: online ahead of print
Journal.
Keywords: Trauma; Childhood abuse; Pain sensitivity; Quantitative sensory testing;

Schrepf A, Kaplan C, Harris RE, Williams DA, Clauw DJ, As-Sanie S, Till S, Clemens JQ, Rodriguez LV, Van Bokhoven A, Landis R, Gallop R, Bradley C, Naliboff B, Pontari M, O'Donnell M, Luo Y, Kreder K, Lutgendorf SK, Harte SE.
Stimulated whole-blood cytokine/chemokine responses are associated with interstitial cystitis/bladder pain syndrome phenotypes and features of nociplastic pain: a multidisciplinary approach to the study of chronic pelvic pain research network study. Pain. 2023 May 1;164(5):1148-1157. doi: 10.1097/j.pain.0000000000002813. PMID: 36279178;
PMC1010635
Journal.
Keywords: Chemokines; Chronic Pain*; Cystitis, Interstitial*; Cytokines / genetics; Female; Pelvic Pain; Phenotype; Quality of Life; Toll-Like Receptor 4

Schrepf AD, Mawla I, Naliboff BD, Gallop B, Moldwin RM, Tu F, Gupta P, Harte S, Krieger JN, Yang C, Bradley C, Rodriguez L, Williams D, Magnotta V, Ichesco E, Harris RE, Clemens Q, Mullins C, Kutch JJ.
Neurobiology and long-term impact of bladder-filling pain in humans: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) research network study. Pain. 2023 Jun 6. doi: 10.1097/j.pain.0000000000002944. Online ahead of print. PMID: 37278657;
PMC1010635
Journal.
Keywords: Chronic pain; Bladder; Urology; Resting-state; fMRI; Flare-up; Healthcare utilization

Stephens-Shields AJ, Lai HH, Landis JR, Kreder K, Rodriguez LV, Naliboff BD, Afari N, Sutcliffe S, Moldwin R, Griffith JW, Clemens JQ, Bradley CS, Quallich S, Gupta P, Harte SE, Farrar JT.
Clinically Important Differences for Pain and Urinary Symptoms in Urological Chronic Pelvic Pain Syndrome: A MAPP Network Study. J Urol. 2023 Jun;209(6):1132-1140. doi: 10.1097/JU.0000000000003394. Epub 2023 Feb 27. PMID: 36848118;
PMCID: In process
Journal.
Keywords: pelvic pain; minimal clinically important difference; treatment outcome; cystitis, interstitial; research design

Sutcliffe S, Newcomb C, Bradley CS, Clemens JQ, Erickson B, Gupta P, Lai HH, Naliboff B, Strachan E, Stephens-Shields A.
Associations Between Urological Chronic Pelvic Pain Syndrome Symptom Flares, Illness Impact, and Health Care Seeking Activity: Findings From the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Symptom Patterns Study. J Urol. 2023 Jan 11:101097JU0000000000003155. doi: 10.1097/JU.0000000000003155. Online ahead of print. PMID: 36630590;
PMC10333444
Journal.
Keywords: cystitis; interstitial; prostatitis; symptom flare up.

Wang C, Kutch JJ, Labus JS, Yang CC, Harris RE, Mayer EA, Ellingson BM.
Reproducible Microstructural Changes in the Brain Associated With the Presence and Severity of Urologic Chronic Pelvic Pain Syndrome (UCPPS): A 3-Year Longitudinal Diffusion Tensor Imaging Study From the MAPP Network. J Pain. 2023 Apr;24(4):627-642. doi: 10.1016/j.jpain.2022.11.008. Epub 2022 Nov 23. PMID: 36435486.
PMCID: online ahead of print
Journal.
Keywords: Urological chronic pelvic pain; UCPPS; Longitudinal observation; Diffusion tensor imaging; Probabilistic tractography;

2022

Bradley CS , Gallop R , Sutcliffe S, Kreder KJ, Lai HH, Clemens JQ, Naliboff BD, for the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.
Long-term Symptom Trajectories in Urologic Chronic Pelvic Pain Syndrome: A MAPP Research Network Study. Urology. 2022 Nov;169:58-64. doi: 10.1016/j.urology.2022.07.045. Epub 2022 Aug 9. PMID: 35961564
PMCID: in process
Journal.
Keywords: Urologic chronic pelvic pain syndrome; interstitial cystitis; chronic prostatitis; bladder pain syndrome; MAPP Networkcohort study; extended follow-up

Froehlich JW, Scott Wang HH, Logvinenko T, Kostel S, DiMartino S, van Bokhoven A, Moses MA, Lee RS; MAPP Research Network.
The urinary proteomic profile implicates key regulators for urologic chronic pelvic pain syndrome (UCPPS): A MAPP Research Network Study. Mol Cell Proteomics.2022 Jan;21(1):100176. doi: 10.1016/j.mcpro.2021.100176. Epub 2021 Nov 11. PMID: 34774759
PMC8733275
Journal.
Keywords: TMT; UCPPS; bladder; inflammation; urine;

Guo WS, You MY, Yi JL, Pontari MA, Landis, JR.
Functional Mixed Effects Clustering with Application to Longitudinal Urologic Chronic Pelvic Pain Syndrome Symptom Data. J Am Stat Assoc. 2022;117(540):1631-1641. doi: 10.1080/01621459.2022.2066536. Epub 2022 May 13. PMID: 36845296
PMC9949755
Journal.
Keywords: Functional clustering; Kullback–Leibler information criterion; Smoothing spline; State space model; EFFECTS MODEL; INFORMATION; PREVALENCE; CYSTITIS;

Gupta P, Gallop R, Spitznagle T, Lai H, Tu F, Krieger JN, Clemens JQ, Bradley CS, Yang C, Sutcliffe S, Moldwin R, Kreder K, Kutch J, Rodriguez LV.
Is Pelvic Floor Muscle Tenderness a Distinct Urologic Chronic Pelvic Pain Syndrome Phenotype? Findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Symptom Pattern Study. J Urol.2022 Aug;208(2):341-349. doi: 10.1097/JU.0000000000002679. Epub 2022 Mar 28. PMID: 35344391
PMC10123541
Journal.
Keywords: pelvic pain; interstitial; cystitis; chronic prostatitis with chronic pelvic pain syndrome

Lai H, Bayman EO, Bishop MO, Landis R, Harte SE, Clemens Q, Rodriguez LV, Sutcliffe S, Taple BJ, Naliboff BD; MAPP Research Network. Longitudinal Changes in the Pelvic Pain Only and Widespread Pain Phenotypes Over One Year in the MAPP-I Urologic Chronic Pelvic Pain Syndrome (UCPPS) Cohort. Urology.2022 Mar;161:31-35. doi: 10.1016/j.urology.2021.12.016. Epub 2022 Jan 10. PMID: 35021046
PMC9502024
Journal.
Keywords: pelvic pain; widespread pain; phenotypes;

Loh-Doyle JC, Stephens-Shields AJ, Rolston R, Newcomb C, Taple B, Sutcliffe S, Yang CC, Lai H, Rodriguez LV.
Predictors of Male Sexual Dysfunction in Urologic Chronic Pelvic Pain Syndrome (UCPPS), Other Chronic Pain Syndromes, and Healthy Controls in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. J Sex Med. 2022 Dec;19(12):1804-1812. doi: 10.1016/j.jsxm.2022.08.196. Epub 2022 Sep 28. PMID: 36180370.
NIHMS1839196
Journal.
Keywords: Erectile Dysfunction; Ejaculatory Dysfunction; Chronic Pelvic Pain; Chronic Prostatitis; Sexual Dysfunction;

Naliboff BD, Locke K Jr, Schrepf D, Griffith JW, Moldwin R, Krieger JN, Rodriguez LV, Stephens-Shields AJ, Clemens JQ, Lai HH, Sutcliffe S, Taple BJ, Williams D, Pontari MA, Mullins C, Landis JR; MAPP Research Network.
Reliability and validity of pain and urinary symptom severity assessment in urologic chronic pelvic pain; A MAPP Network Analysis.J Urol.2022 Jun;207(6):1246-1255. doi: 10.1097/JU.0000000000002438. Epub 2022 Jan 21. PMID: 35060778
PMCID: in process
Journal.
Keywords: chronic prostatitis; interstitial cystitis; pain; urinary symptoms; urologic chronic pelvic pain syndrome;

Nickel JC, Stephens A, Ackerman AL, Anger JT, Lai HH, Ehrlich GD.
The healthy urinary microbiome in asymptomatic participants in the MAPP Network Study: Relation to gender, age, and menopausal status. Can Urol Assoc J. 2022 Sep;16(9):E448-E454. doi: 10.5489/cuaj.7775. PMID: 35426787
PMC9484748
Journal.
Keywords: Microbiome, Urinary, Urinary Tract Infection, Age, Gender

Quallich SA, Quentin CJ, Ronstrom C, James AS, Kreder KJ, Lai HH, Naliboff BD, Rodriguez LV, Berry SH, Sutcliffe S.
Flares and their impact among male urologic chronic pelvic pain syndrome patients: An in-depth qualitative analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. Neurourol Urodyn.2022 Aug;41(6):1468-1481. doi: 10.1002/nau.24983. Epub 2022 Jun 10. PMID: 35686553
PMCID: in process
Journal.
Keywords: chronic prostatitis; diet; focus group; pelvic pain; prostatitis; quality of life; symptom exacerbation; urinary bladder.

Schrepf A, Gallop R, Naliboff B, Harte SE, Afari N, Lai HH, Pontari M, McKernan LC, Strachan E, Kreder KJ, As-Sanie SA, Rodriguez LV, Griffith JW, Williams DA; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.
Clinical Phenotyping for Pain Mechanisms in Urologic Chronic Pelvic Pain Syndromes: A Mapp Research Network Study. J Pain. 2022 Sep;23(9):1594-1603. doi: 10.1016/j.jpain.2022.03.240. Epub 2022 Apr 25. PMID: 35472518;
PMC In Process.
Journal.
Keywords: nociceptive painchronic painneuropathic paincentral nervous system sensitizationcystitis, interstitialprostatitis

2021

Deutsch G, Deshpande H, Lai HH, Kutch JJ, Ness TJ.
Cerebral Perfusion and Sensory Testing Results Differ in Interstitial Cystitis/Bladder Pain Syndrome Patients with and without Fibromyalgia: A Site-Specific MAPP Network Study. J Pain Res. 2021 Dec 23;14:3887-3895. doi: 10.2147/JPR.S343695. eCollection 2021. PMID: 34992450
PMC8711634
Journal.
Keywords: arterial spin labelling, fMRI, interstitial cystitis, QST

Erickson BA, Herman T, Hahn AE, Taple BJ, Bass M, Lloyd RB, Sutcliffe S, Griffith JW.
A Mobile Phone Application for Assessing Daily Variation in Pain Location and Pain Intensity in Patients with Urologic Chronic Pelvic Pain Syndrome: A MAPP Network Study. Urol Pract. 2021 Mar;8(2):189-195. doi: 10.1097/UPJ.0000000000000203. Epub 2020 Oct 14. PMID: 36419906.
PMC9662822
Journal.
Keywords: data collection; prostatitis; mobile applications; ecological momentary assessment.

Javed I, Yu T, Li J, Pakpahan R, Milbrandt M, Andriole GL, Lowder JL, Lai HH, Colditz GA, Sutcliffe S.
Does pollen trigger urological chronic pelvic pain syndrome flares? a case-crossover analysis in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network. J Urol.2021 Apr;205(4):1133-1138. doi: 10.1097/JU.0000000000001482. Epub 2020 Dec 21. PMID: 33347771
PMC9075343
Journal.
Keywords: cystitis, interstitial; pelvic pain; pollen; prostatitis; symptom flare up;

Lai HH, Newcomb C, Harte S, Appleby D, Ackerman AL, Anger JT, Nickel JC, Gupta P, Rodriguez LV, Landis JR, Clemens JQ; MAPP Research Network.
Comparison of deep phenotyping features of UCPPS with and without Hunner lesion: A MAPP-II Research Network Study. Neurourol Urodyn.2021 Mar;40(3):810-818. doi: 10.1002/nau.24623. Epub 2021 Feb 19. PMID: 33604963
PMC8159180
Journal.
Keywords: Hunner lesion; chronic prostatitis; clinical phenotyping; interstitial cystitis; personalized medicine; ulcerative interstitial cystitis;

Naliboff BD, Schrepf AD, Stephens-Shields AJ, Clemens JQ, Pontari MA, Labus J, Taple BJ, Rodriguez LV, Strachan E, Griffith JW.
Temporal relationships between pain, mood and urinary symptoms in urological chronic pelvic pain syndrome: A MAPP Network Study. J Urol.2021 Jun;205(6):1698-1703. doi: 10.1097/JU.0000000000001595. Epub 2021 Feb 4. PMID: 33535797
PMC9179931
Journal.
Keywords: cystitis, interstitial; lower urinary tract symptoms; pain; pelvic pain; prostatitis;

Roy R, Stephens AJ, Daisy C, Merritt L, Newcomb CW, Yang J, Dagher A, Curatolo A, Sachdev M, McNeish B, Landis R, van Bokhoven A, El-Hayek A, Froehlich J, Pontari MA, Zurakowski D, Lee RS, Moses MA.
Association of longitudinal changes in symptoms and urinary biomarkers in patients with urological chronic pelvic pain syndrome: A MAPP Research Network Study. J Urol.2021 Feb;205(2):514-523. doi: 10.1097/JU.0000000000001391. Epub 2020 Oct 7. PMID: 33026902
PMC8139408
Journal.
Keywords: lipocalin-2; matrix metalloproteinases; pelvic pain; vascular endothelial growth factor; vascular endothelial growth factor receptor;

2020

Afari N, Buchwald D, Clauw D, Hong B, Hou X, Krieger JN, Mullins C, Stephens-Shields AJ, Gasperi M, Williams DA; MAPP Research Network.
A MAPP network case-control study of urological chronic pelvic pain compared with nonurological pain conditions. Clin J Pain.2020 Jan;36(1):8-15. doi: 10.1097/AJP.0000000000000769. Epub 2019 Sep 26. PMID: 31794439
PMC7055954
Journal.
Keywords: catastrophizing; chronic fatigue syndrome; fibromyalgia; irritable bowel syndrome; pelvic pain;

Clemens JQ, Kutch JJ, Mayer EA, Naliboff BD, Rodriguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Clauw DJ, Harte SE, Schrepf AD, Williams DA, Andriole GL, Lai HH, Buchwald D, Lucia MS, van Bokhoven A, Mackey S, Moldwin RM, Pontari MA, Stephens-Shields AJ, Mullins C, Landis JR.
The Multidisciplinary Approach to The Study of Chronic Pelvic Pain (MAPP) Research Network*: Design and implementation of the Symptom Patterns Study (SPS). Neurourol Urodyn.2020 Aug;39(6):1803-1814. doi: 10.1002/nau.24423. Epub 2020 Jun 23. PMID: 32578257
PMC8025696
Journal.
Keywords: chronic; interstitial cystitis; plasma biomarkers; prostatitis; urine biomarkers; urological chronic pelvic pain syndromes;

Clemens JQ, Stephens-Shields AJ, Newcomb C, Rodriguez LV, Lai HH, Bradley CS, Naliboff BD, Griffith JW, Taple BJ, Gupta P, Afari N, Harte SE, Strachan E, Guo W, Landis JR.
Correlates of 1-year change in quality of life in patients with urologic chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. J Urol.2020 Oct;204(4):754-759. doi: 10.1097/JU.0000000000001080. Epub 2020 Apr 15. PMID: 32294397
PMC7483873
Journal.
Keywords: cystitis; interstitial; prostatitis;

Fenske SJ, Bierer D, Chelimsky G, Conant L, Ustine C, Yan K, Chelimsky T, Kutch JJ.
Sensitivity of functional connectivity to periaqueductal gray localization, with implications for identifying disease-related changes in chronic visceral pain: A MAPP Research Network neuroimaging study. Neuroimage Clin.2020;28:102443. doi: 10.1016/j.nicl.2020.102443. Epub 2020 Sep 20. PMID: 33027702
PMC7548991
Journal.
Keywords: Brain parcellation; Brainstem; PAG; Resting-state; UCPPS; fMRI;

Holschneider DP, Wang Z, Chang H, Zhang R, Gao Y, Guo Y, Mao J, Rodriguez LV.
Ceftriaxone inhibits stress-induced bladder hyperalgesia and alters cerebral micturition and nociceptive circuits in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study. Neurourol Urodyn.2020 Aug;39(6):1628-1643. doi: 10.1002/nau.24424. Epub 2020 Jun 23. PMID: 32578247
PMC7642011
Journal.
Keywords: animal model; brain mapping; glutamate; micturition; painful bladder syndrome/interstitial cystitis; water avoidance stress;

Holschneider DP, Wang Z, Guo Y, Sanford MT, Yeh J, Mao JJ, Zhang R, Rodriguez LV.
Exercise modulates neuronal activation in the micturition circuit of chronically stressed rats: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study. Physiol Behav.2020 Mar 1;215:112796. doi: 10.1016/j.physbeh.2019.112796. Epub 2019 Dec 27. PMID: 31884113
PMC7269603
Journal.
Keywords: Bladder pain syndrome; Exercise; Functional brain mapping; Interstitial cystitis; Micturition circuit; Psychological stress;

Li J, Yu T, Javed I, Siddagunta C, Pakpahan R, Langston ME, Dennis LK, Kingfield DM, Moore DJ, Andriole GL, Lai HH, Colditz GA, Sutcliffe S; MAPP Research Network.
Does weather trigger urologic chronic pelvic pain syndrome flares? A case-crossover analysis in the multidisciplinary approach to the study of the chronic pelvic pain research network. Neurourol Urodyn.2020 Jun;39(5):1494-1504. doi: 10.1002/nau.24381. Epub 2020 May 4. PMID: 32893408
PMC7479643
Journal.
Keywords: bladder pain syndrome; chronic pelvic pain syndrome; chronic prostatitis; flare; interstitial cystitis; trigger;

Mawla I, Schrepf A, Ichesco E, Harte SE, Klumpp DJ, Griffith JW, Strachan E, Yang CC, Lai H, Andriole G, Magnotta VA, Kreder K, Clauw DJ, Harris RE, Clemens JQ, Landis JR, Mullins C, Rodriguez LV, Mayer EA, Kutch JJ.
Natural bladder filling alters resting brain function at multiple spatial scales: a proof-of-concept MAPP Network Neuroimaging Study. Sci Rep.2020 Nov 16;10(1):19901. doi: 10.1038/s41598-020-76857-x. PMID: 33199816
PMC7669903
Journal.
Keywords: bladder; functional magnetic resonance imaging;

Nickel JC, Stephens A, Landis JR, Mullins C, van Bokhoven A, Anger JT, Ackerman AL, Kim J, Sutcliffe S, Krol JE, Sen B, Hammond J, Ehrlich GD; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.
Urinary fungi associated with urinary symptom severity among women with interstitial cystitis/bladder pain syndrome (IC/BPS). World J Urol.2020 Feb;38(2):433-446. doi: 10.1007/s00345-019-02764-0. Epub 2019 Apr 26. PMID: 31028455
PMC6815247
Journal.
Keywords: Bladder pain syndrome; Flares; Fungal; Interstitial cystitis; Mycobiome;

Robles MTS, Cantalupo PG, Duray AM, Freeland M, Murkowski M, van Bokhoven A, Stephens-Shields AJ, Pipas JM, Imperiale MJ.
Analysis of viruses present in urine from patients with interstitial cystitis. Virus Genes.2020 Aug;56(4):430-438. doi: 10.1007/s11262-020-01767-z. Epub 2020 May 23. PMID: 32447589
PMC7339973
Journal.
Keywords: Interstitial cystitis; NGS; PCR; Polyomavirus; Virus discovery;

Sanford MT, Yeh JC, Mao JJ, Guo Y, Wang Z, Zhang R, Holschneider DP, Rodriguez LV.
Voluntary exercise improves voiding function and bladder hyperalgesia in an animal model of stress-induced visceral hypersensitivity: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome research network study. Neurourol Urodyn.2020 Feb;39(2):603-612. doi: 10.1002/nau.24270. Epub 2020 Jan 13. PMID: 31944369
PMC7043234
Journal.
Keywords: animal model; exercise; interstitial cystitis/bladder pain syndrome; psychological stress;

Yang W, Yaggie RE, Schaeffer AJ, Klumpp DJ.
AOAH remodels arachidonic acid-containing phospholipid pools in a model of interstitial cystitis pain: A MAPP Network study. PLoS One. 2020 Sep 14;15(9):e0235384. doi: 10.1371/journal.pone.0235384. eCollection 2020. PMID: 32925915
PMC7489500
Journal.
Keywords: pain; phospholipids; spinal cord; allodynia; trasferases; lipids; homeostasis; cell membranes;

2019

Ackerman AL, Anger JT, Khalique MU, Ackerman JE, Tang J, Kim J, Underhill DM, Freeman MR; NIH Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP).
Optimization of DNA extraction from human urinary samples for mycobiome community profiling. PLoS One. 2019 Apr 25;14(4):e0210306. doi: 10.1371/journal.pone.0210306. eCollection 2019. PMID: 31022216
PMC6483181
Journal.
Keywords: urine; DNA isolation; centrifugation; DNA extraction; bacteria; fungi; cell disruption; specimen disruption;

Aguiniga LM, Yang W, Yaggie RE, Schaeffer AJ, Klumpp DJ; MAPP Research Network Study Group.
Acyloxyacyl hydrolase modulates depressive-like behaviors through aryl hydrocarbon receptor. Am J Physiol Regul Integr Comp Physiol.2019 Aug 1;317(2):R289-R300. doi: 10.1152/ajpregu.00029.2019. Epub 2019 Apr 24. PMID: 31017816
PMC6732428
Journal.
Keywords: AOAH; AhR; CRF; arachidonic acid; interstitial cystitis; stress;

Clemens JQ, Mullins C, Ackerman AL, Bavendam T, van Bokhoven A, Ellingson BM, Harte SE, Kutch JJ, Lai HH, Martucci KT, Moldwin R, Naliboff BD, Pontari MA, Sutcliffe S, Landis JR; MAPP Research Network Study Group.
Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network. Nat Rev Urol.2019 Mar;16(3):187-200. doi: 10.1038/s41585-018-0135-5. PMID: 30560936
PMC6800057
Journal.
Keywords: bladder disease; chronic pain; prostatitis;

Cui X, Jing X, Lutgendorf SK, Bradley CS, Schrepf A, Erickson BA, Magnotta VA, Ness TJ, Kreder KJ, O'Donnell MA, Luo Y.
Cystitis-induced bladder pain is Toll-like receptor 4 dependent in a transgenic autoimmune cystitis murine model: a MAPP Research Network animal study. Am J Physiol Renal Physiol.2019 Jul 1;317(1):F90-F98. doi: 10.1152/ajprenal.00017.2019. Epub 2019 May 15. PMID: 31091120
PMC6692719
Journal.
Keywords: Multidisciplinary Approach to the Study of Chronic Pelvic Pain; Toll-like receptor 4; cystitis; model; pain;

Gasperi M, Krieger JN, Panizzon MS, Goldberg J, Buchwald D, Afari N.
Genetic and environmental influences on urinary conditions in men: a classical twin study. Urology.2019 Jul;129:54-59. doi: 10.1016/j.urology.2019.04.005. Epub 2019 Apr 13. PMID: 30986484
PMC6592774
Journal.
Keywords: Aged; Diseases in Twins; Gene-Environment Interaction; Humans; Male; Middle Aged; Prostatitis; Urologic Diseases; adult; Article; chronic prostatitis; comorbidity; dizygotic twins; environmental factor; genetic association; heritability; human;

Gupta A, Bhatt RR, Naliboff BD, Kutch JJ, Labus JS, Vora PP, Alaverdyan M, Schrepf A, Lutgendorf S, Mayer EA; MAPP Research Network.
Impact of early adverse life events and sex on functional brain networks in patients with urological chronic pelvic pain syndrome (UCPPS): A MAPP Research Network study. PLoS One. 2019 Jun 20;14(6):e0217610. doi: 10.1371/journal.pone.0217610. eCollection 2019. PMID: 31220089
PMC6586272
Journal.
Keywords: centrality; pain; eigenvectors; neural networks; neuroimaging; caudate nucleus; urology; basal ganglia;

Harte SE, Schrepf A, Gallop R, Kruger GH, Lai HHH, Sutcliffe S, Halvorson M, Ichesco E, Naliboff BD, Afari N, Harris RE, Farrar JT, Tu F, Landis JR, Clauw DJ; MAPP Research Network.
Quantitative assessment of nonpelvic pressure pain sensitivity in urologic chronic pelvic pain syndrome: a MAPP Research Network study. Pain.2019 Jun;160(6):1270-1280. doi: 10.1097/j.pain.0000000000001505. PMID: 31050659
PMC6527452
Journal.
Keywords: Quantitative sensory testing; Pressure pain threshold; Interstitial cystitis; Bladder pain syndrome; Chronic prostatitis; Chronic pelvic pain syndrome; Central sensitization;

Kessler TM.
Flares of chronic pelvic pain syndrome: lessons learned from the MAPP Research Network. BJU Int. 2019 Sep;124(3):360-361. doi: 10.1111/bju.14843. PMID: 31436041.
PMCID: online ahead of print
Journal.
Keywords: chronic pain; chronic disease; pelvic pain;

Lai HH, Vetter J, Song J, Andriole GL, Colditz GA, Sutcliffe S.
Management of symptom flares and patient-reported flare triggers in interstitial cystitis/bladder pain syndrome (ic/bps)-findings from one site of the MAPP Research Network. Urology.2019 Apr;126:24-33. doi: 10.1016/j.urology.2019.01.012. Epub 2019 Jan 22. PMID: 30682464
PMC6874838
Journal.
Keywords: cystitis; interstitial; self report; self management; symptom flare up;

Nickel JC, Stephens-Shields AJ, Landis JR, Mullins C, van Bokhoven A, Lucia MS, Henderson JP, Sen B, Krol JE, Ehrlich GD; MAPP Research Network.
A culture-independent analysis of the microbiota of female interstitial cystitis/bladder pain syndrome participants in the MAPP Research Network. J Clin Med.2019 Mar 26;8(3):415. doi: 10.3390/jcm8030415. PMID: 30917614
PMC6462969
Journal.
Keywords: bladder pain syndrome; infection; interstitial cystitis; microbiome; microbiota;

North CS, Hong BA, Lai HH, Alpers DH.
Assessing somatization in urologic chronic pelvic pain syndrome. BMC Urol.2019 Dec 10;19(1):130. doi: 10.1186/s12894-019-0556-3. PMID: 31823813
PMC6902613
Journal.
Keywords: Chronic prostatitis; Interstitial cystitis; Polysymptomatic; Polysyndromic; Psychiatric diagnosis; Psychoform; Somatization disorder; Somatoform; Symptom screening; Urological chronic pelvic pain syndrome;

Rodríguez LV, Stephens AJ, Clemens JQ, Buchwald D, Yang C, Lai HH, Krieger JN, Newcomb C, Bradley CS, Naliboff B; MAPP Research Network.
Symptom duration in patients with urologic chronic pelvic pain syndrome is not associated with pain severity, nonurologic syndromes and mental health symptoms: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Network Study. Urology.2019 Feb;124:14-22. doi: 10.1016/j.urology.2018.11.015. Epub 2018 Nov 16. PMID: 30452963
PMC7037673
Journal.
Keywords: chronic pain; mental disorders; pain measurement; pelvic pain; severity of illness index; sypmptom assessment;

Sutcliffe S, Gallop R, Henry Lai HH, Andriole GL, Bradley CS, Chelimsky G, Chelimsky T, Quentin Clemens J, Colditz GA, Erickson B, Griffith JW, Kim J, Krieger JN, Labus J, Naliboff BD, Rodriguez LV, Sutherland SE, Taple BJ, Landis JR.
A longitudinal analysis of urological chronic pelvic pain syndrome flares in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int.2019 Sep;124(3):522-531. doi: 10.1111/bju.14783. Epub 2019 May 29. PMID: 31012513
PMC6706296.
Journal.
Keywords: epidemiology; interstitial cystitis; prostatitis; symptom flare-up;

Xu T, Lai HH, Pakpahan R, Vetter J, Andriole GL, Bradley C, Naliboff BD, Colditz GA, Sutcliffe S.
Changes in whole body pain intensity and widespreadness during urologic chronic pelvic pain syndrome flares-Findings from one site of the MAPP study. Neurourol Urodyn.2019 Nov;38(8):2333-2350. doi: 10.1002/nau.24150. Epub 2019 Sep 4. PMID: 31483064
PMC9188843.
Journal.
Keywords: chronic prostatitis; flares; interstitial cystitis; longitudinal study; symptom exacerbations;

2018

Clemens JQ, Stephens-Shields A, Naliboff BD, Lai HH, Rodriguez L, Krieger JN, Williams DA, Kusek JW, Landis JR; MAPP Research Network.
Correlates of health care seeking activities in patients with urological chronic pelvic pain syndromes: findings from the MAPP Cohort. J Urol.2018 Jul;200(1):136-140. doi: 10.1016/j.juro.2017.12.055. Epub 2018 Jan 4. PMID: 29307682
PMC6002941
Journal.
Keywords: cystitis; interstitial; patient acceptance of health care; pelvic pain; prostate; urinary bladder;

Gao Y, Zhang R, Chang HH, Rodríguez LV.
The role of C-fibers in the development of chronic psychological stress induced enhanced bladder sensations and nociceptive responses: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study. Neurourol Urodyn.2018 Feb;37(2):673-680. doi: 10.1002/nau.23374. Epub 2017 Aug 9. PMID: 28792095
PMC5988434
Journal.
Keywords: bladder hypersensitivity; cystometrogram; hyperalgesia; interstitial cystitis; visceromeotor reflex; water avoidance stress;

Kogan P, Xu S, Wang Y, O'Donnell MA, Lutgendorf SK, Bradley CS, Schrepf A, Kreder KJ, Luo Y.
Sub-noxious Intravesical lipopolysaccharide triggers bladder inflammation and symptom onset in a transgenic autoimmune cystitis model: A MAPP Network Animal Study. Sci Rep.2018 Apr 26;8(1):6573. doi: 10.1038/s41598-018-24833-x. PMID: 29700406
PMC5919907
Journal.
Keywords: autoimmunity; experimental models of disease;

Schrepf A, Naliboff B, Williams DA, Stephens-Shields AJ, Landis JR, Gupta A, Mayer E, Rodriguez LV, Lai H, Luo Y, Bradley C, Kreder K, Lutgendorf SK; MAPP Research Network.
Adverse childhood experiences and symptoms of urologic chronic pelvic pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Ann Behav Med.2018 Sep 13;52(10):865-877. doi: 10.1093/abm/kax060. PMID: 30212850
PMC6135957
Journal.
Keywords: Interstitial Cystitis/Painful Bladder Syndrome; Chronic Prostatitis with Chronic Pelvic Pain Syndrome; Psychological Trauma; Sexual Abuse;

Schrepf A, Williams DA, Gallop R, Naliboff BD, Basu N, Kaplan C, Harper DE, Landis JR, Clemens JQ, Strachan E, Griffith JW, Afari N, Hassett A, Pontari MA, Clauw DJ, Harte SE; MAPP Research Network.
Sensory sensitivity and symptom severity represent unique dimensions of chronic pain: a MAPP Research Network study. Pain.2018 Oct;159(10):2002-2011. doi: 10.1097/j.pain.0000000000001299. PMID: 29863527
PMC6705610
Journal.
Keywords: Interstitial cystitis/painful bladder syndrome; Factor analysis, statistical; Fibromyalgia; Central nervous system sensitization; Interoception;

Sutcliffe S, Jemielita T, Lai HH, Andriole GL, Bradley CS, Clemens JQ, Gallop R, Hooton TM, Kreder KJ, Krieger JN, Kusek JW, Labus J, Lucia MS, Mackey S, Naliboff BD, Robinson NA, Rodriguez LV, Stephens-Shields A, van Bokhoven A, Wolin KY, Yan Y, Yang CC, Landis JR, Colditz GA, MAPP Research Network.
A case-crossover study of urological chronic pelvic pain syndrome flare triggers in the MAPP Research Network. J Urol.2018 May;199(5):1245-1251. doi: 10.1016/j.juro.2017.12.050. Epub 2017 Dec 27. PMID: 29288643
PMC5911194
Journal.
Keywords: cystitis; interstitial; prostatitis; surveys and questionnaires; symptom flare up; urinary bladder;

Woodworth DC, Dagher A, Curatolo A, Sachdev M, Ashe-McNalley C, Naliboff BD, Labus JS, Landis JR, Kutch JJ, Mayer EA, Lee RS, Moses MA, Ellingson BM; MAPP Research Network.
Changes in brain white matter structure are associated with urine proteins in urologic chronic pelvic pain syndrome (UCPPS): A MAPP Network study. PLoS One. 2018 Dec 5;13(12):e0206807. doi: 10.1371/journal.pone.0206807. PMID: 30517112
PMC6281196
Journal.
Keywords: urinary biomarkers; diffusion tensor imaging; brainstem; pain; urine; biomarkers; brain; neuroimaging;

Yang CC, Miller JL, Omidpanah A, Krieger JN.
Physical examination for men and women with urologic chronic pelvic pain syndrome: A MAPP (Multidisciplinary Approach to the Study of Chronic Pelvic Pain) Network Study. Urology.2018 Jun;116:23-29. doi: 10.1016/j.urology.2018.03.021. Epub 2018 Mar 28. PMID: 29604315
PMC6237096
Journal.
Keywords: algorithms; anthropometry; chronic pain; cross-sectional studies; cystitis; chronic fatique syndrome; feasibility studies; palpation; pelvic floor disorders; pelvic pain; prostatistis; pudendal nerve;

Yang W, Searl TJ, Yaggie R, Schaeffer AJ, Klumpp DJ.
A MAPP Network study: overexpression of tumor necrosis factor-α in mouse urothelium mimics interstitial cystitis. Am J Physiol Renal Physiol.2018 Jul 1;315(1):F36-F44. doi: 10.1152/ajprenal.00075.2017. Epub 2018 Feb 21. PMID: 29465304
PMC6087793
Journal.
Keywords: TNF; interstitial cystitis; pelvic pain; transgenic mouse model;

Yang W, Yaggie RE, Jiang MC, Rudick CN, Done J, Heckman CJ, Rosen JM, Schaeffer AJ, Klumpp DJ.
Acyloxyacyl hydrolase modulates pelvic pain severity. Am J Physiol Regul Integr Comp Physiol.2018 Mar 1;314(3):R353-R365. doi: 10.1152/ajpregu.00239.2017. Epub 2017 Nov 8. PMID: 29118019
PMC5899250
Journal.
Keywords: AOAH; QTL; allodynia; pelvic pain; pseudorabies virus;

2017

Dagher A, Curatolo A, Sachdev M, Stephens AJ, Mullins C, Landis JR, van Bokhoven A, El-Hayek A, Froehlich JW, Briscoe AC, Roy R, Yang J, Pontari MA, Zurakowski D, Lee RS, Moses MA; MAPP Research Network.
Identification of novel non-invasive biomarkers of urinary chronic pelvic pain syndrome: findings from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int.2017 Jul;120(1):130-142. doi: 10.1111/bju.13832. Epub 2017 Apr 11. PMID: 28263447
PMC5951631
Journal.
Keywords: Lipocalin 2 (also known as NGAL); Multidisciplinary Approach to the Study of Chronic Pelvic Pain; matrix metalloproteinase; neutrophil gelatinase associated lipocalin; vascular endothelial growth factor; vascular endothelial growth factor receptor 1;

Gasperi M, Krieger JN, Forsberg C, Goldberg J, Buchwald D, Afari N.
Chronic prostatitis and comorbid non-urological overlapping pain conditions: A co-twin control study. J Psychosom Res.2017 Nov;102:29-33. doi: 10.1016/j.jpsychores.2017.09.005. Epub 2017 Sep 6. PMID: 28992894
PMC5683425
Journal.
Keywords: Chronic fatigue syndrome; Chronic pelvic pain syndrome; Chronic prostatitis; Comorbidity; Discordant twins; Fibromyalgia; Irritable bowel syndrome; Lower urinary tract symptoms; Migraine headaches; Temporomandibular joint disorder; Twin research;

Harper DE, Ichesco E, Schrepf A, Halvorson M, Puiu T, Clauw DJ, Harris RE, Harte SE; MAPP Research Network.
Relationships between brain metabolite levels, functional connectivity, and negative mood in urologic chronic pelvic pain syndrome patients compared to controls: A MAPP research network study. Neuroimage Clin.2017 Nov 15;17:570-578. doi: 10.1016/j.nicl.2017.11.014. eCollection 2018. PMID: 29201643
PMC5702874
Journal.
Keywords: Centralized pain; Choline; Gamma aminobutyric acid (GABA); Interstitial cystitis; MAPP; Proton magnetic resonance spectroscopy;

Kutch JJ, Ichesco E, Hampson JP, Labus JS, Farmer MA, Martucci KT, Ness TJ, Deutsch G, Apkarian AV, Mackey SC, Klumpp DJ, Schaeffer AJ, Rodriguez LV, Kreder KJ, Buchwald D, Andriole GL, Lai HH, Mullins C, Kusek JW, Landis JR, Mayer EA, Clemens JQ, Clauw D, Harris RE, MAPP Research Network.
Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study. Pain.2017 Oct;158(10):1979-1991. doi: 10.1097/j.pain.0000000000001001. PMID: 28692006
PMC5964335
Journal.
Keywords: Centralized; Chronic; Pain; fMRI; Widespread; Fibromyalgia; Pelvic; VBM; Connectivity;

Kutch JJ, Labus JS, Harris RE, Martucci KT, Farmer MA, Fenske S, Fling C, Ichesco E, Peltier S, Petre B, Guo W, Hou X, Stephens AJ, Mullins C, Clauw DJ, Mackey SC, Apkarian AV, Landis JR, Mayer EA; MAPP Research Network.
Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study. Pain.2017 Jun;158(6):1069-1082. doi: 10.1097/j.pain.0000000000000886. PMID: 28328579
PMC5435510

Keywords: Neuroimaging; Prediction; Chronic pain; Urologic pain;

Lai HH, Jemielita T, Sutcliffe S, Bradley CS, Naliboff B, Williams DA, Gereau RW 4th, Kreder K, Clemens JQ, Rodriguez LV, Krieger JN, Farrar JT, Robinson N, Landis JR; MAPP Research Network.
Characterization of whole-body pain in urological chronic pelvic pain syndrome at baseline: A MAPP Research Network Study. J Urol.2017 Sep;198(3):622-631. doi: 10.1016/j.juro.2017.03.132. Epub 2017 Mar 31. PMID: 28373134
PMC5562525
Journal.
Keywords: cystitis; interstitial; pelvic pain; prostate; prostatitis; urinary bladder;

Lai HH, Shen B, Vijairania P, Zhang X, Vogt SK, Gereau RW 4th.
Anti-vascular endothelial growth factor treatment decreases bladder pain in cyclophosphamide cystitis: a Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network animal model study. BJU Int.2017 Oct;120(4):576-583. doi: 10.1111/bju.13924. Epub 2017 Jun 29. PMID: 28581681
PMC5716917
Journal.
Keywords: bladder pain; cyclophosphamide cystitis; interstitial cystitis; vascular endothelial growth factor anti-VEGF;

Naliboff BD, Stephens AJ, Lai HH, Griffith JW, Clemens JQ, Lutgendorf S, Rodriguez LV, Newcomb C, Sutcliffe S, Guo W, Kusek JW, Landis JR; MAPP Research Network.
Clinical and psychosocial predictors of urological chronic pelvic pain symptom change in 1 year: a prospective study from the MAPP Research Network. J Urol.2017 Oct;198(4):848-857. doi: 10.1016/j.juro.2017.05.065. Epub 2017 May 18. PMID: 28528930
PMC5720154
Journal.
Keywords: cystitis; interstitial; pelvic pain; prostate; prostatitis; urinary bladder;

Wang Z, Chang HH, Gao Y, Zhang R, Guo Y, Holschneider DP, Rodriguez LV.
Effects of water avoidance stress on peripheral and central responses during bladder filling in the rat: A multidisciplinary approach to the study of urologic chronic pelvic pain syndrome (MAPP) research network study. PLoS One. 2017 Sep 8;12(9):e0182976. doi: 10.1371/journal.pone.0182976. eCollection 2017. PMID: 28886046
PMC5590813
Journal.
Keywords: bladder; urination; psychological stress; sensory perception; pain; motor cortex; pain sensation; thalamus;

2016

Afari N, Gasperi M, Forsberg CW, Goldberg J, Buchwald D, Krieger JN.
Heritability of lower urinary tract symptoms in men: a twin study. J Urol.2016 Nov;196(5):1486-1492. doi: 10.1016/j.juro.2016.06.018. Epub 2016 Jun 14. PMID: 27312318
PMC5069121
Journal.
Keywords: heritable; lower urinary tract symptoms; quantitative trait; twins;

Alger JR, Ellingson BM, Ashe-McNalley C, Woodworth DC, Labus JS, Farmer M, Huang L, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Deutsch G, Harris RE, Clauw DJ, Glover GH, Parrish TB, Hollander Jd, Kusek JW, Mullins C, Mayer EA; MAPP Research Network Investigators.
Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network. Neuroimage Clin.2016 Jan 6;12:65-77. doi: 10.1016/j.nicl.2015.12.009. eCollection 2016. PMID: 27408791
PMC4925887
Journal.
Keywords: Brain; DTI; Diffusion tensor imaging; Functional magnetic resonance imaging; Magnetic resonance imaging; TransMAPP; Urologic chronic pelvic pain syndromes;

Deutsch G, Deshpande H, Frölich MA, Lai HH, Ness TJ.
Bladder distension increases blood flow in pain related brain structures in subjects with interstitial cystitis. J Urol.2016 Sep;196(3):902-10. doi: 10.1016/j.juro.2016.03.135. Epub 2016 Mar 24. PMID: 27018508
PMC5014638
Journal.
Keywords: brain; cerebrovascular circulation; cystitis, interstitial; pain; urinary bladder;

Godfrey KM, Strachan E, Mostoufi S, Poeschla B, Succop A, Afari N.
Familial contributions to self-reported sleep and pain in female twins. Pain Med.2016 Jan;17(1):33-9. doi: 10.1111/pme.12894. PMID: 26271474
PMC4753149
Journal.
Keywords: Pain; Sleep; Females; Twins; Genetics; Familial Factors; pain; twins; sleep; chronic pain; self-report;

Griffith JW, Stephens-Shields AJ, Hou X, Naliboff BD, Pontari M, Edwards TC, Williams DA, Clemens JQ, Afari N, Tu F, Lloyd RB, Patrick DL, Mullins C, Kusek JW, Sutcliffe S, Hong BA, Lai HH, Krieger JN, Bradley CS, Kim J, Landis JR.
Pain and urinary symptoms should not be combined into a single score: psychometric findings from the MAPP Research Network. J Urol.2016 Apr;195(4 Pt 1):949-54. doi: 10.1016/j.juro.2015.11.012. Epub 2015 Nov 14. PMID: 26585679
PMC4867140
Journal.
Keywords: chronic pain; cystitis, interstitial; factor analysis, statistical; prostatitis; urinary bladder;

Huang L, Kutch JJ, Ellingson BM, Martucci KT, Harris RE, Clauw DJ, Mackey S, Mayer EA, Schaeffer AJ, Apkarian AV, Farmer MA; MAPP Research Network.
Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study. Pain.2016 Dec;157(12):2782-2791. doi: 10.1097/j.pain.0000000000000703. PMID: 27842046
PMC5117992
Journal.
Keywords: Pain; Urological; Pelvic; Irritable bowel syndrome; Diffusion tensor imaging;

Kleinhans NM, Yang CC, Strachan ED, Buchwald DS, Maravilla KR.
Alterations in connectivity on functional magnetic resonance imaging with provocation of lower urinary tract symptoms: A MAPP Research Network Feasibility Study of Urological Chronic Pelvic Pain Syndromes. J Urol.2016 Mar;195(3):639-45. doi: 10.1016/j.juro.2015.09.092. Epub 2015 Oct 22. PMID: 26497778
PMC5035686
Journal.
Keywords: brain; cystitis; interstitial; magnetic resonance imaging; pain; urinary bladder;

Kutch JJ, Tu FF.
Altered brain connectivity in dysmenorrhea: pain modulation and the motor cortex. Pain.2016 Jan;157(1):5-6. doi: 10.1097/j.pain.0000000000000364. PMID: 26683107
PMC4941100
Journal.
Keywords: brain; brain mapping; dysmenorrhea; magnetic resonance imaging; motor cortex; nerve net; neural pathways;

Nickel JC, Stephens A, Landis JR, Mullins C, van Bokhoven A, Lucia MS, Ehrlich GD; MAPP Research Network.
Assessment of the lower urinary tract microbiota during symptom flare in women with urologic chronic pelvic pain syndrome: A MAPP Network Study. J Urol.2016 Feb;195(2):356-62. doi: 10.1016/j.juro.2015.09.075. Epub 2015 Sep 26. PMID: 26410734
PMC4770794
Journal.
Keywords: cystitis; infection; interstitial; microbiota; symptom assessment;

Parker KS, Crowley JR, Stephens-Shields AJ, van Bokhoven A, Lucia MS, Lai HH, Andriole GL, Hooton TM, Mullins C, Henderson JP.
Urinary metabolomics identifies a molecular correlate of interstitial cystitis/bladder pain syndrome in a multidisciplinary approach to the study of chronic pelvic pain (MAPP) research network cohort. EBioMedicine.2016 May;7:167-74. doi: 10.1016/j.ebiom.2016.03.040. Epub 2016 Mar 31. PMID: 27322470
PMC4909380
Journal.
Keywords: biomarkers; cystitis; interstitial; mass spectrometry; pain mesurement; steroids/urine; sulfates/urine; steroids; sulfates;

Schrepf A, O'Donnell MA, Luo Y, Bradley CS, Kreder KJ, Lutgendorf SK.
Inflammation and symptom change in interstitial cystitis or bladder pain syndrome: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Study. Urology.2016 Apr;90:56-61. doi: 10.1016/j.urology.2015.12.040. Epub 2016 Jan 6. PMID: 26768711
PMC4892365
Journal.
Keywords: Adult; Cystitis, Interstitial; Female; Humans; Inflammation; Longitudinal Studies; Prospective Studies; hydrocortisone; toll like receptor 2; toll like receptor 4; adult; Article; clinical article; cystalgia; female; human; hypothalamus hypophysis adrenal

Stephens-Shields AJ, Clemens JQ, Jemielita T, Farrar J, Sutcliffe S, Hou X, Landis JR; MAPP Research Network.
Symptom variability and early symptom regression in the mapp study: a prospective study of urological chronic pelvic pain syndrome. J Urol.2016 Nov;196(5):1450-1455. doi: 10.1016/j.juro.2016.04.070. Epub 2016 Apr 27. PMID: 27131464
PMC5069105
Journal.
Keywords: cystitis; epidemiologic research design; interstitial; pain; prostate; symptom assessment;

Wang X, Liu W, O'Donnell M, Lutgendorf S, Bradley C, Schrepf A, Liu L, Kreder K, Luo Y.
Evidence for the role of mast cells in cystitis-associated lower urinary tract dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study. PLoS One. 2016 Dec 21;11(12):e0168772. doi: 10.1371/journal.pone.0168772. eCollection 2016. PMID: 28002455
PMC5176179
Journal.
Keywords: mast cells; bladder; cystitis; mouse models; inflammation; urination; habits; pain;

Williams DA.
Cognitive - behavioral therapy in central sensitivity syndromes. Curr Rheumatol Rev.2016;12(1):2-12. doi: 10.2174/157339711201160303103241. PMID: 26717953
Journal.
Keywords: BioPsychoSocial; central sensitivity syndromes; chronic overlapping pain conditions; cognitive behavioral therapy;

Xu S, Wang X, Wang Y, Lutgendorf S, Bradley C, Schrepf A, Kreder K, O'Donnell M, Luo Y.
Transgenic mice expressing mcp-1 by the urothelium demonstrate bladder hypersensitivity, pelvic pain and voiding dysfunction: A Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network Animal Model Study. PLoS One. 2016 Sep 29;11(9):e0163829. doi: 10.1371/journal.pone.0163829. eCollection 2016. PMID: 27684718
PMC5042429
Journal.
Keywords: bladder; mouse models; inflammation; pain; genetically modified animals; cystitis; habits; urination;

2015

Clemens JQ, Clauw DJ, Kreder K, Krieger JN, Kusek JW, Lai HH, Rodriguez L, Williams DA, Hou X, Stephens A, Landis JR; MAPP Research Network.
Comparison of baseline urological symptoms in men and women in the MAPP research cohort. J Urol.2015 May;193(5):1554-8. doi: 10.1016/j.juro.2014.11.016. Epub 2014 Nov 13. PMID: 25463989
PMC4454891
Journal.
Keywords: chronic pain; cystitis; interstitial; pelvic pain; prostatitis;

Farmer MA, Huang L, Martucci K, Yang CC, Maravilla KR, Harris RE, Clauw DJ, Mackey S, Ellingson BM, Mayer EA, Schaeffer AJ, Apkarian AV; MAPP Research Network.
Brain white matter abnormalities in female interstitial cystitis/bladder pain syndrome: A MAPP Network Neuroimaging Study. J Urol.2015 Jul;194(1):118-26. doi: 10.1016/j.juro.2015.02.082. Epub 2015 Feb 21. PMID: 25711200
PMC4475466
Journal.
Keywords: cystitis; diffusion tensor imaging; interstitial; pain; urinary bladder; white matter;

Kairys AE, Schmidt-Wilcke T, Puiu T, Ichesco E, Labus JS, Martucci K, Farmer MA, Ness TJ, Deutsch G, Mayer EA, Mackey S, Apkarian AV, Maravilla K, Clauw DJ, Harris RE.
Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome. J Urol.2015 Jan;193(1):131-7. doi: 10.1016/j.juro.2014.08.042. Epub 2014 Aug 14. PMID: 25132239
PMC4435781
Journal.
Keywords: cystitis; interstitial; pain; somatosensory cortex;

Krieger JN, Stephens AJ, Landis JR, Clemens JQ, Kreder K, Lai HH, Afari N, Rodríguez L, Schaeffer A, Mackey S, Andriole GL, Williams DA; MAPP Research Network.
Relationship between chronic nonurological associated somatic syndromes and symptom severity in urological chronic pelvic pain syndromes: baseline evaluation of the MAPP study. J Urol.2015 Apr;193(4):1254-62. doi: 10.1016/j.juro.2014.10.086. Epub 2014 Oct 22. PMID: 25444992
PMC4497586
Journal.
Keywords: cystitis; female; interstitial; male; questionnaires; urinary bladder;

Kutch JJ, Yani MS, Asavasopon S, Kirages DJ, Rana M, Cosand L, Labus JS, Kilpatrick LA, Ashe-McNalley C, Farmer MA, Johnson KA, Ness TJ, Deutsch G, Harris RE, Apkarian AV, Clauw DJ, Mackey SC, Mullins C, Mayer EA.
Altered resting state neuromotor connectivity in men with chronic prostatitis/chronic pelvic pain syndrome: A MAPP: Research Network Neuroimaging Study. Neuroimage Clin.2015 Jun 5;8:493-502. doi: 10.1016/j.nicl.2015.05.013. eCollection 2015. PMID: 26106574
PMC4474411
Journal. Keywords: Adult; Chronic Disease; Cohort Studies; Functional Neuroimaging; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Motor Cortex; Nerve Net; Pelvic Pain; Prostatitis; brain mapping; Brief Pain Inventory; chronic prostatitis; clinical article;

Lai H, Gereau RW 4th, Luo Y, O'Donnell M, Rudick CN, Pontari M, Mullins C, Klumpp DJ.
Animal models of urologic chronic pelvic pain syndromes: findings from the multidisciplinary approach to the study of chronic pelvic pain research network. Urology.2015 Jun;85(6):1454-65. doi: 10.1016/j.urology.2015.03.007. PMID: 26099889
PMC4479414
Journal.
Keywords: Animals; Cystitis, Interstitial; Disease Models, Animal; Humans; Male; Mice; Prostatitis; abdomen; allodynia; animal experiment; animal model; Article; bladder disease; bladder distention; blotting; clinical research; controlled study; cystalgia; cystome

Lai HH, Krieger JN, Pontari MA, Buchwald D, Hou X, Landis JR; MAPP Research Network.
Painful bladder filling and painful urgency are distinct characteristics in men and women with urological chronic pelvic pain syndromes: A MAPP Research Network Study. J Urol.2015 Dec;194(6):1634-41. doi: 10.1016/j.juro.2015.05.105. Epub 2015 Jul 17. PMID: 26192257
PMC4669971
Journal.
Keywords: cystitis; interstitial; pain; prostatitis; questionnaires; urinary bladder;

Martucci KT, Shirer WR, Bagarinao E, Johnson KA, Farmer MA, Labus JS, Apkarian AV, Deutsch G, Harris RE, Mayer EA, Clauw DJ, Greicius MD, Mackey SC.
The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network. Pain.2015 Sep;156(9):1755-1764. doi: 10.1097/j.pain.0000000000000238. PMID: 26010458
PMC4545714
Journal.
Keywords: UCPPS; Interstitial cystitis; Bladder pain syndrome; Posterior cingulate cortex; Default mode network; DMN; Precuneus; Dual regression; Resting state; fMRI;

Naliboff BD, Stephens AJ, Afari N, Lai H, Krieger JN, Hong B, Lutgendorf S, Strachan E, Williams D; MAPP Research Network.
Widespread psychosocial difficulties in men and women with urologic chronic pelvic pain syndromes: case-control findings from the multidisciplinary approach to the study of chronic pelvic pain research network. Urology.2015 Jun;85(6):1319-27. doi: 10.1016/j.urology.2015.02.047. PMID: 26099876
PMC4479402
Journal.
Keywords: chronic pain; pelvic pain; severity of illness index; urologic diseases;

Nickel JC, Stephens A, Landis JR, Chen J, Mullins C, van Bokhoven A, Lucia MS, Melton-Kreft R, Ehrlich GD; MAPP Research Network.
Search for microorganisms in men with urologic chronic pelvic pain syndrome: a culture-independent analysis in the MAPP Research Network. J Urol.2015 Jul;194(1):127-35. doi: 10.1016/j.juro.2015.01.037. Epub 2015 Jan 14. PMID: 25596358
PMC4475477
Journal.
Keywords: chronic pain; infection; microbiota; pelvic pain; prostatitis;

Schrepf A, Bradley CS, O'Donnell M, Luo Y, Harte SE, Kreder K, Lutgendorf S; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.
Toll-like receptor 4 and comorbid pain in Interstitial Cystitis/Bladder Pain Syndrome: a multidisciplinary approach to the study of chronic pelvic pain research network study. Brain Behav Immun.2015 Oct;49:66-74. doi: 10.1016/j.bbi.2015.03.003. Epub 2015 Mar 11. PMID: 25771510
PMC4567436
Journal.
Keywords: Functional somatic syndromes; Inflammation; Interstitial Cystitis/Bladder Pain Syndrome; Negative affect; Pain; Toll-like Receptors;

Sutcliffe S, Bradley CS, Clemens JQ, James AS, Konkle KS, Kreder KJ, Lai HH, Mackey SC, Ashe-McNalley CP, Rodriguez LV, Barrell E, Hou X, Robinson NA, Mullins C, Berry SH.
Urological chronic pelvic pain syndrome flares and their impact: qualitative analysis in the MAPP network. Int Urogynecol J.2015 Jul;26(7):1047-60. doi: 10.1007/s00192-015-2652-6. Epub 2015 Mar 20. PMID: 25792349
PMC4489981
Journal.
Keywords: urological chronic pelvic pain syndrome; interstitial cystitis; bladder pain syndrome; symptom exacerbation; flare; focus group;

Sutcliffe S, Colditz GA, Pakpahan R, Bradley CS, Goodman MS, Andriole GL, Lai HH.
Changes in symptoms during urologic chronic pelvic pain syndrome symptom flares: findings from one site of the MAPP Research Network. Neurourol Urodyn.2015 Feb;34(2):188-95. doi: 10.1002/nau.22534. Epub 2013 Nov 23. PMID: 24273163
PMC4032370
Journal.
Keywords: bladder pain syndrome; chronic pelvic pain syndrome; chronic prostatitis; flare; interstitial cystitis; symptom exacerbation;

Woodworth D, Mayer E, Leu K, Ashe-McNalley C, Naliboff BD, Labus JS, Tillisch K, Kutch JJ, Farmer MA, Apkarian AV, Johnson KA, Mackey SC, Ness TJ, Landis JR, Deutsch G, Harris RE, Clauw DJ, Mullins C, Ellingson BM; MAPP Research Network.
Unique microstructural changes in the brain associated with urological chronic pelvic pain syndrome (UCPPS) revealed by diffusion tensor MRI, super-resolution track density imaging, and statistical parameter mapping: A MAPP Network Neuroimaging Study. PLoS One. 2015 Oct 13;10(10):e0140250. doi: 10.1371/journal.pone.0140250. eCollection 2015. PMID: 26460744
PMC4604194
Journal.
Keywords: pain; central nervous system; corpus callosum; diffusion tensor imaging; basal ganglia; microstructure; anisotropy; pain sensation;

2014

Bagarinao E, Johnson KA, Martucci KT, Ichesco E, Farmer MA, Labus J, Ness TJ, Harris R, Deutsch G, Apkarian VA, Mayer EA, Clauw DJ, Mackey S.
Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study. Pain.2014 Dec;155(12):2502-2509. doi: 10.1016/j.pain.2014.09.002. Epub 2014 Sep 19. PMID: 25242566
PMC4504202
Journal.
Keywords: Gray matter density; Machine learning; SVM; Support vector machine; UCPPS;

Clemens JQ, Mullins C, Kusek JW, Kirkali Z, Mayer EA, Rodríguez LV, Klumpp DJ, Schaeffer AJ, Kreder KJ, Buchwald D, Andriole GL, Lucia MS, Landis JR, Clauw DJ; MAPP Research Network Study Group.
The MAPP research network: a novel study of urologic chronic pelvic pain syndromes. BMC Urol.2014 Aug 1;14:57. doi: 10.1186/1471-2490-14-57. PMID: 25085007
PMC4134515
Journal.
Keywords: urological chronic pelvic pain syndromes, interstitial cystitis, chronic prostatitis, translational research, multi-disciplinary;

Jonscher KR, Osypuk AA, van Bokhoven A, Lucia MS.
Evaluation of urinary protein precipitation protocols for the multidisciplinary approach to the study of chronic pelvic pain research network. J Biomol Tech.2014 Dec;25(4):118-26. doi: 10.7171/jbt.14-2504-004. PMID: 25365794
PMC4211279
Keywords: chemical precipitation; proteomics; quantitation; urine;

Kilpatrick LA, Kutch JJ, Tillisch K, Naliboff BD, Labus JS, Jiang Z, Farmer MA, Apkarian AV, Mackey S, Martucci KT, Clauw DJ, Harris RE, Deutsch G, Ness TJ, Yang CC, Maravilla K, Mullins C, Mayer EA.
Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome. J Urol.2014 Sep;192(3):947-55. doi: 10.1016/j.juro.2014.03.093. Epub 2014 Mar 26. PMID: 24681331
PMC4432915
Journal.
Keywords: brain mapping; cystitis; interstitial; magnetic resonance imaging; pain; urinary bladder;

Lai HH, North CS, Andriole GL, Cupps L, Song D, Ness TJ, Hong BA.
Urological symptoms in a subset of patients with urological chronic pelvic pain syndrome and a polysymptomatic, polysyndromic pattern of presentation. J Urol.2014 Jun;191(6):1802-7. doi: 10.1016/j.juro.2013.12.031. Epub 2013 Dec 19. PMID: 24361369
PMC4411959
Journal.
Keywords: chronic pain; cystitis; interstitial; prostatitis; somatosensory disorders; urinary bladder;

Landis JR, Williams DA, Lucia MS, Clauw DJ, Naliboff BD, Robinson NA, van Bokhoven A, Sutcliffe S, Schaeffer AJ, Rodriguez LV, Mayer EA, Lai HH, Krieger JN, Kreder KJ, Afari N, Andriole GL, Bradley CS, Griffith JW, Klumpp DJ, Hong BA, Lutgendorf SK, Buchwald D, Yang CC, Mackey S, Pontari MA, Hanno P, Kusek JW, Mullins C, Clemens JQ; MAPP Research Network Study Group.
The MAPP research network: design, patient characterization and operations. BMC Urol.2014 Aug 1;14:58. doi: 10.1186/1471-2490-14-58. PMID: 25085119
PMC4126395
Journal.
Keywords: urologic chronic pelvic pain syndromes, interstitial cystitis, chronic prostatitis, urine biomarkers, plasma biomarkers, non-urologic associated syndromes, quantitative sensory testing (QST), neuroimaging;

Rudick CN, Taylor AK, Yaggie RE, Schaeffer AJ, Klumpp DJ.
Asymptomatic bacteriuria Escherichia coli are live biotherapeutics for UTI. PLoS One. 2014 Nov 18;9(11):e109321. doi: 10.1371/journal.pone.0109321. eCollection 2014. PMID: 25405579
PMC4236008
Journal.
Keywords: allodynia; analgesics; pain; gladder; bacterial pathogens; urinary tract infections; antimicrobial resistance; escherichia coli infections;

Schrepf A, O'Donnell M, Luo Y, Bradley CS, Kreder K, Lutgendorf S; Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network.
Inflammation and inflammatory control in interstitial cystitis/bladder pain syndrome: Associations with painful symptoms. Pain.2014 Sep;155(9):1755-1761. doi: 10.1016/j.pain.2014.05.029. Epub 2014 Jun 5. PMID: 24907404
PMC4166494
Journal.
Keywords: Bladder pain syndrome; Hypothalamic–pituitary–adrenal axis; Inflammation; Interstitial cystitis; Pelvic pain; Toll-like receptors;

Sutcliffe S, Colditz GA, Goodman MS, Pakpahan R, Vetter J, Ness TJ, Andriole GL, Lai HH.
Urological chronic pelvic pain syndrome symptom flares: characterisation of the full range of flares at two sites in the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network. BJU Int.2014 Dec;114(6):916-25. doi: 10.1111/bju.12778. Epub 2014 Aug 11. PMID: 24730356
PMC4198521
Journal.
Keywords: bladder pain syndrome; chronic pelvic pain syndrome; chronic prostatitis; flare; interstitial cystitis; symptom exacerbation;

2013

Bullones Rodríguez MÁ, Afari N, Buchwald DS; National Institute of Diabetes and Digestive and Kidney Diseases Working Group on Urological Chronic Pelvic Pain.
Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol.2013 Jan;189(1 Suppl):S66-74. doi: 10.1016/j.juro.2012.11.019. PMID: 23234637
PMC9159381
Journal. Keywords: urogenital system; chronic; fibromyalgia; irritable bowel syndrome; temporomandibular joint disorders; fatigue syndrome;

Harte SE, Mitra M, Ichesco EA, Halvorson ME, Clauw DJ, Shih AJ, Kruger GH.
Development and validation of a pressure-type automated quantitative sensory testing system for point-of-care pain assessment. Med Biol Eng Comput.2013 Jun;51(6):633-44. doi: 10.1007/s11517-013-1033-x. Epub 2013 Feb 5. PMID: 23381890
Journal.
Keywords: chronic pain; fibromyalgia; MAST; pressure pain threshold;

Stemler KM, Crock LW, Lai HH, Mills JC, Gereau RW 4th and Mysorekar IU.
Protamine sulfate-induced bladder injury protects from distention induced bladder pain. J Urol.2013 Jan;189(1): 343-51. doi: 10.1016/j.juro.2012.08.189. Epub 2012 Nov 20. PMID: 23174261
PMC3662487
Journal.
Keywords: inflammation; nociception; urinary bladder; protamines; pain;

Williams DA.
The importance of psychological assessment in chronic pain. Curr Opin Urol.2013 Nov;23(6):554-9. doi: 10.1097/MOU.0b013e3283652af1. PMID: 24080806
PMC4295636
Journal.
Keywords: affect; cognition; pain perception; modulation;

2012

Chaturvedi KS, Hung CS, Crowley JR, Stapleton AE, Henderson JP.
The siderophore yersiniabactin binds copper to protect pathogens during infection. Nat Chem Biol.2012 Aug;8(8):731-6. doi: 10.1038/nchembio.1020. Epub 2012 Jul 8. PMID: 22772152
PMC3600419
Journal.
Keywords: bacterial pathogenesis; chemical genetics; iron

Crock LW, Kolber BJ, Morgan CD, Sadler KE, Vogt SK, Bruchas MR, Gereau RW 4th.
Central amygdala metabotropic glutamate receptor 5 in the modulation of visceral pain. J Neurosci.2012 Oct 10;32(41):14217-26. doi: 10.1523/JNEUROSCI.1473-12.2012. PMID: 23055491
PMC3494864
Journal.
Keywords: amygdala/physiology; NAP kinase signaling system; pain measurement; metabotropic glutamate 5; viseral pain; Grm5 protein;

Kim R, Liu W, Chen X, Kreder KJ, Luo Y.
Intravesical dimethyl sulfoxide inhibits acute and chronic bladder inflammation in transgenic experimental autoimmune cystitis models. J Biomed Biotechnol.2011;2011:937061. doi: 10.1155/2011/937061. Epub 2010 Nov 11. PMID: 21113298
PMC2989383
Journal.
Keywords: acute disease; autoimmune dieseases; cystitis; chronic disease; dimethyl sulfoxide; dose-response relationship; epitopes; spleen/cytology; urinary bladder diseases;

Lai HH, North CS, Andriole GL, Sayuk GS, Hong BA.
Polysymptomatic, polysyndromic presentation of patients with urological chronic pelvic pain syndrome. J Urol.2012 Jun;187(6):2106-12. doi: 10.1016/j.juro.2012.01.081. Epub 2012 Apr 12. PMID: 22503014
PMC3957225
Journal.
Keywords: prostatitis; urinary bladder; cystitis, interstitial; somatization disorders; prostate;

Rudick CN, Jiang M, Yaggie RE, Pavlov VI, Done J, Heckman CJ, Whitfield C, Schaeffer AJ, Klumpp DJ.
O-antigen modulates infection-induced pain states. PLoS One. 2012;7(8):e41273. doi: 10.1371/journal.pone.0041273. Epub 2012 Aug 10. PMID: 22899994
PMC3416823
Journal.
Keywords: pain; allodynia; bladder; inflammation; spinal cord; neutrophils; bacterial pathogens; hypersensitivity;

2011

Lai HH, Qiu CS, Crock LW, Morales MEP, Ness TJ, Gereau RW 4th.
Activation of spinal extracellular signal-regulated kinases (ERK) 1/2 is associated with the development of visceral hyperalgesia of the bladder. Pain.2011 Sep;152(9):2117-2124. doi: 10.1016/j.pain.2011.05.017. Epub 2011 Jun 25. PMID: 21705143
PMC3157542
Journal.
Keywords: Urinary bladder; Visceral pain; Inflammatory pain; Visceromotor response; ERK signaling; Central sensitization;

Lv H, Hung CS, Chaturvedi KS, Hooton TM, Henderson JP.
Development of an integrated metabolomic profiling approach for infectious diseases research. Analyst.2011 Nov 21;136(22):4752-63. doi: 10.1039/c1an15590c. Epub 2011 Sep 16. PMID: 21922104
PMC3746514
Journal.
Keywords: chromatography; escherichia coli/pathogenicity; mass spectrometry; metabolomics; phenotype; urniaty tract infections;

Lv H, Henderson JP.
Yersinia high pathogenicity island genes modify the Escherichia coli primary metabolome independently of siderophore production. J Proteome Res.2011 Dec 2;10(12):5547-54. doi: 10.1021/pr200756n. Epub 2011 Nov 15. PMID: 22035238
PMC3626101
Journal.
Keywords: Metabolomics; Peptides and proteins; Metabolism; Monomer; Biosynthesis;

2009

Rodríguez MÁ, Afari N, Buchwald DS.
Evidence for overlap between urological and nonurological unexplained clinical conditions. J Urol.2009 Nov;182(5):2123-31. doi: 10.1016/j.juro.2009.07.036. Epub 2009 Sep 16. PMID: 19758633
PMC2957306
Journal.
Keywords: chronic; urogenital system; temporomandibular joint disorders; irritable bowel syndrome; fibromyalgia; fatigue syndrome;

Page update: August 17, 2023